This course has two objectives: to introduce the basic concepts of information systems and to analyze their impact on companies’ strategy and business models, both traditional and new ones based on digital infrastructures. Information system within an organization is the system needed to obtain, store, process, and distribute information relevant to planning, execution, and monitoring of an organization’s activities. Part of the course is devoted to the classical topics in information systems management. Other sessions focus on issues of planning and implementing information systems, as well as their impact on the organizational structure. The course also examines how to ensure that the business strategy is coherent. Finally, issues related to managing IT/IS are examined, including knowledge management, outsourcing and management via ERPs, in order to conclude with a reflection on the real importance of information systems in companies today.